Vaccine antigens coupled to an antibody (green) that binds to carbohydrates on M cells (right) induce a stronger immune response than when coupled to lectins (red).

Pathogens that invade the mucosa are better repelled if the vaccines against them are delivered to the right target cells. Nochi et al. (page 2789) now identify an antibody that delivers vaccines to super-absorbent cells lining mucosal surfaces.

In mucosal tissues such as the airways and digestive tract, immune responses are only weakly stimulated by injected vaccines, which are taken up by circulating cells that boost systemic immunity. Local immunity is more effectively generated by ingested or inhaled vaccines that can be taken up directly by lymphoid tissues in the gut and airway. These tissues are lined by microvilli-bearing M cells that soak up the vaccines and pass them along to the immunity-inducing dendritic cells and macrophages lurking...

The Rockefeller University Press
2007
The Rockefeller University Press
2007
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