In vivo sites and cellular mechanisms of T reg cell–mediated suppression

Rudensky , Alexander Y.; Campbell , Daniel J.

doi:10.1084/jem.20060214

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Commentary| March 13 2006

In vivo sites and cellular mechanisms of T reg cell–mediated suppression

Alexander Y. Rudensky,

Alexander Y. Rudensky

A.Y.R. is at Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195.

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Daniel J. Campbell

D.J.C. is at Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195 and Benaroya Research Institute, Seattle, WA 98101.

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Author and Article Information

Alexander Y. Rudensky

A.Y.R. is at Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195.

Daniel J. Campbell

D.J.C. is at Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195 and Benaroya Research Institute, Seattle, WA 98101.

CORRESPONDENCE A.Y.R.: [email protected] OR D.J.C.: [email protected]

Online ISSN: 1540-9538

Print ISSN: 0022-1007

The Rockefeller University Press

2006

J Exp Med (2006) 203 (3): 489–492.

https://doi.org/10.1084/jem.20060214

Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell–T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies.

The Rockefeller University Press

2006

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