Tumor necrosis factor receptor (TNFR)–associated factor 2 (TRAF2) and TRAF1 were found as components of the TNFR2 signaling complex, which exerts multiple biological effects on cells such as cell proliferation, cytokine production, and cell death. In the TNFR2-mediated signaling pathways, TRAF2 works as a mediator for activation signals such as NF-κB, but the role of TRAF1 has not been previously determined. Here we show in transgenic mice that TRAF1 overexpression inhibits antigen-induced apoptosis of CD8+ T lymphocytes. Our results demonstrate a biological role for TRAF1 as a regulator of apoptotic signals and also support the hypothesis that the combination of TRAF proteins in a given cell type determines distinct biological effects triggered by members of the TNF receptor superfamily.
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19 May 1997
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May 19 1997
A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
Daniel E. Speiser,
Daniel E. Speiser
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Soo Young Lee,
Soo Young Lee
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Brian Wong,
Brian Wong
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Joseph Arron,
Joseph Arron
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Angela Santana,
Angela Santana
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Young-Yun Kong,
Young-Yun Kong
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Pamela S. Ohashi,
Pamela S. Ohashi
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Yongwon Choi
Yongwon Choi
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
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Daniel E. Speiser,
Soo Young Lee,
Brian Wong,
Joseph Arron,
Angela Santana,
Young-Yun Kong,
Pamela S. Ohashi,
Yongwon Choi
From the *Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, Toronto, Ontario M5G 2M9, Canada; and the ‡Howard Hughes Medical Institute and §The Rockefeller University, New York 10021
Address correspondence to Yongwon Choi, HHMI, The Rockefeller University, 1230 York Avenue, Box 295, New York, NY 10021.
1Abbreviations used in this paper: GP, glycoprotein; LCMV, lymphocytic choriomeningitis virus; PI, propidium iodide; SEB, staphylococcal enterotoxin B; TNFR, tumor necrosis factor receptor.
The first two authors contributed equally to this report.
Pamela S. Ohashi and Yongwon Choi share senior authorship.
Received:
January 14 1997
Revision Received:
March 10 1997
Online ISSN: 1540-9538
Print ISSN: 0022-1007
1997
J Exp Med (1997) 185 (10): 1777–1783.
Article history
Received:
January 14 1997
Revision Received:
March 10 1997
Citation
Daniel E. Speiser, Soo Young Lee, Brian Wong, Joseph Arron, Angela Santana, Young-Yun Kong, Pamela S. Ohashi, Yongwon Choi; A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells. J Exp Med 19 May 1997; 185 (10): 1777–1783. doi: https://doi.org/10.1084/jem.185.10.1777
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