BRAIN-ASSOCIATED STEM CELL ANTIGEN: AN ANTIGEN SHARED BY BRAIN AND HEMOPOIETIC STEM CELLS

Golub , Edward S.

doi:10.1084/jem.136.2.369

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Brief Definitive Report| August 01 1972

BRAIN-ASSOCIATED STEM CELL ANTIGEN: AN ANTIGEN SHARED BY BRAIN AND HEMOPOIETIC STEM CELLS

Edward S. Golub

From the Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907

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Author and Article Information

Edward S. Golub

From the Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907

Received: May 15 1972

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1972

J Exp Med (1972) 136 (2): 369–374.

https://doi.org/10.1084/jem.136.2.369

There is an antigen on mouse brain tissue which is shared by the hemopoietic colony-forming unit or stem cell of the mouse. Treatment of bone marrow or fetal liver cells with anti-brain antisera inhibits expression of colony-forming units. The anti-stem cell antibody is not absorbed by thymus cells and thus can be distinguished from the anti-thymocyte antibody which these antisera also contain.

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