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Systematic membrane thickness variation across cellular organelles revealed by cryo-ET

Desislava Glushkova, Stefanie Böhm, Martin Beck

J Cell Biol (2025) 225 (1): e202504053.

https://doi.org/10.1083/jcb.202504053

Published: 04 November 2025

View article titled, Systematic membrane thickness variation across cellular organelles revealed by cryo-ET

Journal Articles

A pyrophosphatase that regulates lipid precursors of N-glycosylation

Anant K. Menon

J Cell Biol (2025) 224 (11): e202509041.

https://doi.org/10.1083/jcb.202509041

Published: 10 October 2025

View article titled, A pyrophosphatase that regulates lipid precursors of N-glycosylation

Journal Articles

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

Kevin A. Swift, Iryna Pustova, William Kasberg, Jenna Bowman, Krithi Gopinath, Erin Voss, Hayden Nelson, Anjon Audhya

J Cell Biol (2025) 224 (12): e202407013.

https://doi.org/10.1083/jcb.202407013

Published: 08 October 2025

View article titled, Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

Includes: Supplementary data

Journal Articles

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Sheng-Tao Li, Katsuhiko Kamada, Akinobu Honda, Junichi Seino, Tsugiyo Matsuda, Takehiro Suzuki, Naoshi Dohmae, Yuichi Shichino, Shintaro Iwasaki, Yoichi Noda, Michael Costanzo, Charles Boone, Tadashi Suzuki

J Cell Biol (2025) 224 (11): e202501239.

https://doi.org/10.1083/jcb.202501239

Published: 29 September 2025

View article titled, LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Includes: Supplementary data

Journal Articles

Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics

Anbang Dai, Peng Xu, Chase Amos, Kenshiro Fujise, Yumei Wu, Han Yang, Julia N. Eisen, Andrés Guillén-Samander, Pietro De Camilli

J Cell Biol (2025) 224 (11): e202504027.

https://doi.org/10.1083/jcb.202504027

Published: 03 September 2025

View article titled, Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics

Includes: Supplementary data

Journal Articles

Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

Bing Han, Sarah M. Connolly, Darrin T. Schultz, Louis F.L. Wilson, Alican Gulsevin, Jens Meiler, Erkan Karakas, Melanie D. Ohi, Anne K. Kenworthy

J Cell Biol (2025) 224 (9): e202411175.

https://doi.org/10.1083/jcb.202411175

Published: 07 August 2025

View article titled, Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

Includes: Supplementary data

Journal Articles

AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Benjamin S. Padman, Runa S.J. Lindblom, Michael Lazarou

J Cell Biol (2025) 224 (10): e202411138.

https://doi.org/10.1083/jcb.202411138

Published: 30 July 2025

View article titled, AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Journal Articles

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation

Brigitte S. Naughton, Swapnil C. Devarkar, Vanessa Todorow, Sunanda Mallik, Stacey Oxendine, Sanjana Junnarkar, Yuan Ren, Julien Berro, Janine Kirstein, Yong Xiong, Christian Schlieker

J Cell Biol (2025) 224 (9): e202505010.

https://doi.org/10.1083/jcb.202505010

Published: 15 July 2025

View article titled, Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation

Includes: Supplementary data

Journal Articles

Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains

Sabina Elmi, Jesper Nylandsted

J Cell Biol (2025) 224 (7): e202505027.

https://doi.org/10.1083/jcb.202505027

Published: 18 June 2025

View article titled, Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains

Journal Articles

Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair

In Special Collection:

The Year in Cell Biology: 2025

Justin Krish Williams, Jordan Matthew Ngo, Abinayaa Murugupandiyan, Dorothy E. Croall, H. Criss Hartzell, Randy Schekman

J Cell Biol (2025) 224 (7): e202408159.

https://doi.org/10.1083/jcb.202408159

Published: 16 May 2025

View article titled, Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair

Includes: Supplementary data

Journal Articles

Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins

Yumeng Wan, Yuri L. Nemoto, Tsukasa Oikawa, Kazunori Takano, Takahiro K. Fujiwara, Kazuya Tsujita, Toshiki Itoh

J Cell Biol (2025) 224 (7): e202411024.

https://doi.org/10.1083/jcb.202411024

Published: 08 May 2025

View article titled, Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins

Includes: Supplementary data

Journal Articles

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Taylor E. Lange, Ali Naji, Ransome van der Hoeven, Hong Liang, Yong Zhou, Gerald R.V. Hammond, John F. Hancock, Kwang-jin Cho

J Cell Biol (2025) 224 (7): e202403126.

https://doi.org/10.1083/jcb.202403126

Published: 02 May 2025

View article titled, MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Includes: Supplementary data

Journal Articles

Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin

Tatsuki Isogai, Koichiro M. Hirosawa, Miki Kanno, Ayano Sho, Rinshi S. Kasai, Naoko Komura, Hiromune Ando, Keiko Furukawa, Yuhsuke Ohmi, Koichi Furukawa, Yasunari Yokota, Kenichi G.N. Suzuki

J Cell Biol (2025) 224 (6): e202404064.

https://doi.org/10.1083/jcb.202404064

Published: 30 April 2025

View article titled, Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin

Includes: Supplementary data

Journal Articles

Mitochondrial mayhem: Disrupting conserved N-terminal motifs in TANGO2 impacts its localization and function

Sarah E. Sandkuhler, Samuel J. Mackenzie

J Cell Biol (2025) 224 (5): e202503010.

https://doi.org/10.1083/jcb.202503010

Published: 15 April 2025

View article titled, Mitochondrial mayhem: Disrupting conserved N-terminal motifs in TANGO2 impacts its localization and function

Journal Articles

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

Kunyou Park, Sungeun Ju, Hyewon Choi, Peng Gao, Geul Bang, Jung Hoon Choi, Jiwon Jang, Andrew J. Morris, Byung-Ho Kang, Victor W. Hsu, Seung-Yeol Park

J Cell Biol (2025) 224 (5): e202407166.

https://doi.org/10.1083/jcb.202407166

Published: 11 April 2025

View article titled, PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

Includes: Supplementary data

Journal Articles

The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks

Rong Sun, James P. Allen, Zhuqing Mao, Liana Wilson, Mariam Haider, Baris Alten, Zimeng Zhou, Xinyi Wang, Qiangjun Zhou

J Cell Biol (2025) 224 (6): e202406133.

https://doi.org/10.1083/jcb.202406133

Published: 27 March 2025

View article titled, The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks

Journal Articles

Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P₂

Jing Ze Wu, Joshua G. Pemberton, Shin Morioka, Junko Sasaki, Priya Bablani, Takehiko Sasaki, Tamas Balla, Sergio Grinstein, Spencer A. Freeman

J Cell Biol (2025) 224 (6): e202408174.

https://doi.org/10.1083/jcb.202408174

Published: 26 March 2025

View article titled, Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2

Includes: Supplementary data

Journal Articles

Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity

Yazhen Huo, Xinlu Liu, Chen Lu, Tao Li, Zaili Yang, Fenfen Xu, Si Chen, Kailin Yin, Likun Wang

J Cell Biol (2025) 224 (5): e202405060.

https://doi.org/10.1083/jcb.202405060

Published: 26 March 2025

View article titled, Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity

Includes: Supplementary data

Journal Articles

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate

Joshua G. Pemberton, Isobel Barlow-Busch, Meredith L. Jenkins, Matthew A.H. Parson, Farkas Sarnyai, Seyma Nur Bektas, Yeun Ju Kim, John E. Heuser, John E. Burke, Tamas Balla

J Cell Biol (2025) 224 (6): e202408158.

https://doi.org/10.1083/jcb.202408158

Published: 26 March 2025

View article titled, An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate

Includes: Supplementary data

Journal Articles

SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics

Laura Trachsel-Moncho, Chiara Veroni, Benan John Mathai, Ana Lapao, Sakshi Singh, Nagham Theres Asp, Sebastian W. Schultz, Serhiy Pankiv, Anne Simonsen

J Cell Biol (2025) 224 (5): e202404009.

https://doi.org/10.1083/jcb.202404009

Published: 07 March 2025

View article titled, SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics

Includes: Supplementary data

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Systematic membrane thickness variation across cellular organelles revealed by cryo-ET

A pyrophosphatase that regulates lipid precursors of N-glycosylation

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics

Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation

Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains

Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair

Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin

Mitochondrial mayhem: Disrupting conserved N-terminal motifs in TANGO2 impacts its localization and function

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

The postsynaptic density in excitatory synapses is composed of clustered, heterogeneous nanoblocks

Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P₂

Ceramide mediates cell-to-cell ER stress transmission by modulating membrane fluidity

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate

SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics

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