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Landscape expansion microscopy reveals interactions between membrane and phase-separated organelles

Yinyin Zhuang, Zhao Zhang, Zhipeng Dai, Xiaoyu Shi

J Cell Biol (2026) 225 (4): e202502035.

https://doi.org/10.1083/jcb.202502035

Published: 27 January 2026

View article titled, Landscape expansion microscopy reveals interactions between membrane and phase-separated organelles

Journal Articles

Cholesterol depletion activates trafficking-coupled sphingolipid synthesis

Yeongho Kim, Jan Parolek, Christopher G. Burd

J Cell Biol (2026) 225 (4): e202502083.

https://doi.org/10.1083/jcb.202502083

Published: 20 January 2026

View article titled, Cholesterol depletion activates trafficking-coupled sphingolipid synthesis

Includes: Supplementary data

Journal Articles

Stepwise assembly of α-hemolysin from intermediates to the mature pore in native erythrocytes

Arnab Chatterjee, Anupam Roy, Partho Pratim Das, Debajyoti Chakraborty, Bartika Ghoshal, Siddharth Jhunjhunwala, Somnath Dutta

J Cell Biol (2026) 225 (3): e202506129.

https://doi.org/10.1083/jcb.202506129

Published: 12 January 2026

View article titled, Stepwise assembly of α-hemolysin from intermediates to the mature pore in native erythrocytes

Includes: Supplementary data

Journal Articles

The cell biologist’s guide to detecting and modulating membrane phospholipids

In Special Collection:

Reproducibility and Best Practices in Cell Biology

Michael Worcester, Morgan M.C. Ricci, Claire C. Weckerly, Jesus G. Calixto, Gerald R.V. Hammond

J Cell Biol (2026) 225 (2): e202508058.

https://doi.org/10.1083/jcb.202508058

Published: 02 January 2026

View article titled, The cell biologist’s guide to detecting and modulating membrane phospholipids

Journal Articles

Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments

Michaela Medina, Ya-Ting Chang, Hamidreza Rahmani, Mark Frank, Zidan Khan, Daniel Fuentes, Frederick A. Heberle, M. Neal Waxham, Benjamin A. Barad, Danielle A. Grotjahn

J Cell Biol (2025) 225 (3): e202505059.

https://doi.org/10.1083/jcb.202505059

Published: 26 December 2025

View article titled, Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments

Journal Articles

Ist2 is a phospholipid scramblase that links lipid transport at the ER to organelle homeostasis

Heitor Gobbi Sebinelli, Camille Syska, Hafez Razmazma, Véronique Albanèse, Ana Rita Dias Araujo, Cecile Hilpert, Cédric Montigny, Christine Jaxel, Manuella Tchamba, Karolina Belingar, Juan Martín D’Ambrosio, Luca Monticelli, Guillaume Lenoir, Alenka Čopič

J Cell Biol (2025) 225 (2): e202502112.

https://doi.org/10.1083/jcb.202502112

Published: 26 December 2025

View article titled, Ist2 is a phospholipid scramblase that links lipid transport at the ER to organelle homeostasis

Includes: Supplementary data

Journal Articles

TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion

Jianfei Zheng, Haodong Wang, Yuxin Sun, Pei Chang, Xing Deng, Lijingyao Zhang, Lin Zhu, Kangling Zhu, Dong Peng, Haiteng Deng, Min Zhang, Liang Ge

J Cell Biol (2025) 225 (1): e202503075.

https://doi.org/10.1083/jcb.202503075

Published: 09 December 2025

View article titled, TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion

Includes: Supplementary data

Journal Articles

Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion

Evgenia Leikina, Andrey K. Tsaturyan, Kamran Melikov, Jarred M. Whitlock, Jared Cunanan, Morgan Roegner, Griffin Katz, Michael M. Kozlov, Leonid V. Chernomordik

J Cell Biol (2025) 225 (2): e202508055.

https://doi.org/10.1083/jcb.202508055

Published: 02 December 2025

View article titled, Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion

Includes: Supplementary data

Journal Articles

Systematic membrane thickness variation across cellular organelles revealed by cryo-ET

Desislava Glushkova, Stefanie Böhm, Martin Beck

J Cell Biol (2025) 225 (1): e202504053.

https://doi.org/10.1083/jcb.202504053

Published: 04 November 2025

View article titled, Systematic membrane thickness variation across cellular organelles revealed by cryo-ET

Journal Articles

A pyrophosphatase that regulates lipid precursors of N-glycosylation

Anant K. Menon

J Cell Biol (2025) 224 (11): e202509041.

https://doi.org/10.1083/jcb.202509041

Published: 10 October 2025

View article titled, A pyrophosphatase that regulates lipid precursors of N-glycosylation

Journal Articles

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

Kevin A. Swift, Iryna Pustova, William Kasberg, Jenna Bowman, Krithi Gopinath, Erin Voss, Hayden Nelson, Anjon Audhya

J Cell Biol (2025) 224 (12): e202407013.

https://doi.org/10.1083/jcb.202407013

Published: 08 October 2025

View article titled, Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

Includes: Supplementary data

Journal Articles

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Sheng-Tao Li, Katsuhiko Kamada, Akinobu Honda, Junichi Seino, Tsugiyo Matsuda, Takehiro Suzuki, Naoshi Dohmae, Yuichi Shichino, Shintaro Iwasaki, Yoichi Noda, Michael Costanzo, Charles Boone, Tadashi Suzuki

J Cell Biol (2025) 224 (11): e202501239.

https://doi.org/10.1083/jcb.202501239

Published: 29 September 2025

View article titled, LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Includes: Supplementary data

Journal Articles

Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics

Anbang Dai, Peng Xu, Chase Amos, Kenshiro Fujise, Yumei Wu, Han Yang, Julia N. Eisen, Andrés Guillén-Samander, Pietro De Camilli

J Cell Biol (2025) 224 (11): e202504027.

https://doi.org/10.1083/jcb.202504027

Published: 03 September 2025

View article titled, Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics

Includes: Supplementary data

Journal Articles

Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

Bing Han, Sarah M. Connolly, Darrin T. Schultz, Louis F.L. Wilson, Alican Gulsevin, Jens Meiler, Erkan Karakas, Melanie D. Ohi, Anne K. Kenworthy

J Cell Biol (2025) 224 (9): e202411175.

https://doi.org/10.1083/jcb.202411175

Published: 07 August 2025

View article titled, Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

Includes: Supplementary data

Journal Articles

AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Benjamin S. Padman, Runa S.J. Lindblom, Michael Lazarou

J Cell Biol (2025) 224 (10): e202411138.

https://doi.org/10.1083/jcb.202411138

Published: 30 July 2025

View article titled, AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Journal Articles

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation

Brigitte S. Naughton, Swapnil C. Devarkar, Vanessa Todorow, Sunanda Mallik, Stacey Oxendine, Sanjana Junnarkar, Yuan Ren, Julien Berro, Janine Kirstein, Yong Xiong, Christian Schlieker

J Cell Biol (2025) 224 (9): e202505010.

https://doi.org/10.1083/jcb.202505010

Published: 15 July 2025

View article titled, Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation

Includes: Supplementary data

Journal Articles

Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains

Sabina Elmi, Jesper Nylandsted

J Cell Biol (2025) 224 (7): e202505027.

https://doi.org/10.1083/jcb.202505027

Published: 18 June 2025

View article titled, Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains

Journal Articles

Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair

In Special Collection:

The Year in Cell Biology: 2025

Justin Krish Williams, Jordan Matthew Ngo, Abinayaa Murugupandiyan, Dorothy E. Croall, H. Criss Hartzell, Randy Schekman

J Cell Biol (2025) 224 (7): e202408159.

https://doi.org/10.1083/jcb.202408159

Published: 16 May 2025

View article titled, Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair

Includes: Supplementary data

Journal Articles

Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins

Yumeng Wan, Yuri L. Nemoto, Tsukasa Oikawa, Kazunori Takano, Takahiro K. Fujiwara, Kazuya Tsujita, Toshiki Itoh

J Cell Biol (2025) 224 (7): e202411024.

https://doi.org/10.1083/jcb.202411024

Published: 08 May 2025

View article titled, Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins

Includes: Supplementary data

Journal Articles

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Taylor E. Lange, Ali Naji, Ransome van der Hoeven, Hong Liang, Yong Zhou, Gerald R.V. Hammond, John F. Hancock, Kwang-jin Cho

J Cell Biol (2025) 224 (7): e202403126.

https://doi.org/10.1083/jcb.202403126

Published: 02 May 2025

View article titled, MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

Includes: Supplementary data

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Landscape expansion microscopy reveals interactions between membrane and phase-separated organelles

Cholesterol depletion activates trafficking-coupled sphingolipid synthesis

Stepwise assembly of α-hemolysin from intermediates to the mature pore in native erythrocytes

The cell biologist’s guide to detecting and modulating membrane phospholipids

Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments

Ist2 is a phospholipid scramblase that links lipid transport at the ER to organelle homeostasis

TMEDs mediate versatile cargo transport in vesicle-dependent unconventional secretion

Phosphatidylserine exposure and annexin A5 weaken the actin cortex in osteoclast fusion

Systematic membrane thickness variation across cellular organelles revealed by cryo-ET

A pyrophosphatase that regulates lipid precursors of N-glycosylation

Analysis of native Ist1 dynamics reveals multiple pools of ESCRT-III on endosomes

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide

Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics

Evolutionarily diverse caveolins share a common structural framework built around amphipathic disks

AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation

Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains

Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair

Mechanical control of osteoclast fusion by membrane-cortex attachment and BAR proteins

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

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