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Shigeki Higashiyama
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Journal Articles

The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB

Igor Kovačević, Tomohisa Sakaue, Jisca Majoleé, Manon C. Pronk, Masashi Maekawa, Dirk Geerts, Mar Fernandez-Borja, Shigeki Higashiyama, Peter L. Hordijk
Journal: Journal of Cell Biology
J Cell Biol (2018) 217 (3): 1015–1032.
https://doi.org/10.1083/jcb.201606055
Published: 22 January 2018
View articletitled, The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB
Open the PDF for The Cullin-3–Rbx1–KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB in another window
Includes: Supplementary data
Journal Articles

Cell motion predicts human epidermal stemness

Daisuke Nanba, Fujio Toki, Sota Tate, Matome Imai, Natsuki Matsushita, Ken Shiraishi, Koji Sayama, Hiroshi Toki, Shigeki Higashiyama, Yann Barrandon
Journal: Journal of Cell Biology
J Cell Biol (2015) 209 (2): 305–315.
https://doi.org/10.1083/jcb.201409024
Published: 20 April 2015
View articletitled, Cell motion predicts human epidermal stemness
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Includes: Multimedia, Supplementary data
Journal Articles

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

Begoña Díaz, Angela Yuen, Shinji Iizuka, Shigeki Higashiyama, Sara A. Courtneidge
Journal: Journal of Cell Biology
J Cell Biol (2013) 201 (2): 279–292.
https://doi.org/10.1083/jcb.201209151
Published: 15 April 2013
View articletitled, Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia
Open the PDF for Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia in another window
Includes: Supplementary data
Journal Articles

Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane

Miki Hieda, Mayumi Isokane, Michiko Koizumi, Chiduru Higashi, Taro Tachibana, Masachika Shudou, Tomohiko Taguchi, Yohki Hieda, Shigeki Higashiyama
Journal: Journal of Cell Biology
J Cell Biol (2008) 180 (4): 763–769.
https://doi.org/10.1083/jcb.200710022
Published: 25 February 2008
View articletitled, Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane
Open the PDF for Membrane-anchored growth factor, HB-EGF, on the cell surface targeted to the inner nuclear membrane in another window
Includes: Supplementary data
Journal Articles

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Sahin, Gisela Weskamp, Kristine Kelly, Hong-Ming Zhou, Shigeki Higashiyama, Jacques Peschon, Dieter Hartmann, Paul Saftig, Carl P. Blobel
Journal: Journal of Cell Biology
J Cell Biol (2004) 164 (5): 769–779.
https://doi.org/10.1083/jcb.200307137
Published: 01 March 2004
View articletitled, Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
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Journal Articles

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

Daisuke Nanba, Akiko Mammoto, Koji Hashimoto, Shigeki Higashiyama
Journal: Journal of Cell Biology
J Cell Biol (2003) 163 (3): 489–502.
https://doi.org/10.1083/jcb.200303017
Published: 03 November 2003
View articletitled, Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
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Journal Articles

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

Satoru Yamazaki, Ryo Iwamoto, Kazuko Saeki, Masanori Asakura, Seiji Takashima, Ayano Yamazaki, Rina Kimura, Hiroto Mizushima, Hiroki Moribe, Shigeki Higashiyama, Masayuki Endoh, Yasufumi Kaneda, Satoshi Takagi, Satoshi Itami, Naoki Takeda, Gen Yamada, Eisuke Mekada
Journal: Journal of Cell Biology
J Cell Biol (2003) 163 (3): 469–475.
https://doi.org/10.1083/jcb.200307035
Published: 03 November 2003
View articletitled, Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities
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Includes: Supplementary data
Journal Articles

Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing

Sho Tokumaru, Shigeki Higashiyama, Takeshi Endo, Takatoshi Nakagawa, Jun-ichiro Miyagawa, Katsumi Yamamori, Yasushi Hanakawa, Hiroshi Ohmoto, Kohichiro Yoshino, Yuji Shirakata, Yuji Matsuzawa, Koji Hashimoto, Naoyuki Taniguchi
Journal: Journal of Cell Biology
J Cell Biol (2000) 151 (2): 209–220.
https://doi.org/10.1083/jcb.151.2.209
Published: 16 October 2000
View articletitled, Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing
Open the PDF for Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing in another window