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Stem Cells and Development 2018

Throughout embryonic development and adult life, multicellular organisms depend upon the functioning and tight regulation of self-renewing stem cells that harbor different degrees of potency. These cells are thought to be implicated in the formation of tumors and play important roles in age-related pathologies. Knowledge of the mechanisms that ensure stem cell origin, function and fate, how they respond to the microenvironment, and orchestrate organ development and regeneration is instrumental in understanding healthy development, tissue homeostasis throughout life, and tumor initiation and dissemination.

JCB Editorial Board Member Maria-Elena Torres-Padilla and Senior Scientific Editor Melina Casadio assembled a collection of highly read recent JCB papers investigating morphogenesis, pluripotency and reprogramming, as well as stem cell function during adulthood, aging, and in diseases such as cancer. From 3D culture systems and human stem cell work to model systems, this collection harnesses the power of cell biology to examine the molecular and cellular mechanisms at the center of stem cell behavior and development, in particular in the embryo, germline, nervous system, intestine, bone marrow, and hematopoietic system. The selected studies highlight the complexity of the cell biological, epigenetic, genetic, and signaling mechanisms governing stem cell function and development. We hope you enjoy this special collection and look forward to your feedback on Facebook and Twitter.

Image © 2018 Carroll et al.

Special Collection Image
Thomas D. Carroll; Ian P. Newton; Yu Chen; J. Julian Blow; Inke Näthke
DOI: 10.1083/jcb.201708023
Ling Guo; Ting Cai; Keng Chen; Rong Wang; Jiaxin Wang; Chunhong Cui; Jifan Yuan; Kuo Zhang; Zhongzhen Liu; Yi Deng; Guozhi Xiao; Chuanyue Wu
DOI: 10.1083/jcb.201612177
Joshua Kavaler; Hong Duan; Rajaguru Aradhya; Luis F. de Navas; Brian Joseph; Boris Shklyar; Eric C. Lai
DOI: 10.1083/jcb.201706101
Brice E. Keyes; Elaine Fuchs
DOI: 10.1083/jcb.201708099
Tamás Csizmadia; Péter Lőrincz; Krisztina Hegedűs; Szilvia Széplaki; Péter Lőw; Gábor Juhász
DOI: 10.1083/jcb.201702145
Kenichiro Taniguchi; Yue Shao; Ryan F. Townshend; Chari L. Cortez; Clair E. Harris; Sasha Meshinchi; Sundeep Kalantry; Jianping Fu; K. Sue O’Shea; Deborah L. Gumucio
DOI: 10.1083/jcb.201704085
Annalisa Izzo; Céline Ziegler-Birling; Peter W.S. Hill; Lydia Brondani; Petra Hajkova; Maria-Elena Torres-Padilla; Robert Schneider
DOI: 10.1083/jcb.201611012
Christopher L. Koehler; Guy A. Perkins; Mark H. Ellisman; D. Leanne Jones
DOI: 10.1083/jcb.201610036
Chenran Wang; Syn Yeo; Michael A. Haas; Jun-Lin Guan
DOI: 10.1083/jcb.201609093
Gregoire Stik; Simon Crequit; Laurence Petit; Jennifer Durant; Pierre Charbord; Thierry Jaffredo; Charles Durand
DOI: 10.1083/jcb.201601109
Yanxin Li; Jianwei Jiao
DOI: 10.1083/jcb.201610014
Tokiro Ishikawa; Takuya Toyama; Yuki Nakamura; Kentaro Tamada; Hitomi Shimizu; Satoshi Ninagawa; Tetsuya Okada; Yasuhiro Kamei; Tomoko Ishikawa-Fujiwara; Takeshi Todo; Eriko Aoyama; Masaharu Takigawa; Akihiro Harada; Kazutoshi Mori
DOI: 10.1083/jcb.201609100
Xia Tang; Jianan Gao; Xinling Jia; Wencao Zhao; Yijie Zhang; Weijun Pan; Jie He
DOI: 10.1083/jcb.201611057
Pamela Riemer; Mattias Rydenfelt; Matthias Marks; Karen van Eunen; Kathrin Thedieck; Bernhard G. Herrmann; Nils Blüthgen; Christine Sers; Markus Morkel
DOI: 10.1083/jcb.201610058
Istvan Foldi; Niki Anthoney; Neale Harrison; Monique Gangloff; Brett Verstak; Mohanakarthik Ponnadai Nallasivan; Samaher AlAhmed; Bangfu Zhu; Mark Phizacklea; Maria Losada-Perez; Marta Moreira; Nicholas J. Gay; Alicia Hidalgo
DOI: 10.1083/jcb.201607098
Chun-Ming Lai; Kun-Yang Lin; Shih-Han Kao; Yi-Ning Chen; Fu Huang; Hwei-Jan Hsu
DOI: 10.1083/jcb.201610063
Sérgio Simões; Youjin Oh; Michael F.Z. Wang; Rodrigo Fernandez-Gonzalez; Ulrich Tepass
DOI: 10.1083/jcb.201608038
Julia König; E.B. Frankel; Anjon Audhya; Thomas Müller-Reichert
DOI: 10.1083/jcb.201607030
Shaohe Wang; Rei Sekiguchi; William P. Daley; Kenneth M. Yamada
DOI: 10.1083/jcb.201610048
Daniel Cirera-Salinas; Jian Yu; Maxime Bodak; Richard P. Ngondo; Kristina M. Herbert; Constance Ciaudo
DOI: 10.1083/jcb.201606073
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