Stem Cells and Development 2019
Throughout embryonic development and adult life, stem cells are crucial to the function of tissues and organs, and they are also implicated in tumor development and disease pathogenesis. Better understanding stem cell function, origin and fate, how they respond to their microenvironment and participate in development and regeneration as well as knowledge of the fundamental mechanisms of tissue, organ, and organism development are crucial to understand how stem cell dysfunction contributes to disease and cancer and how cancer cells co-opt developmental mechanisms to enable tumor growth and progression. JCB Editorial Board member Cédric Blanpain and Deputy Editor Tim Spencer are delighted to present this collection of recent JCB papers about the cell biology of stem cells and development. In this collection, we highlight recent work published in JCB deciphering the mechanisms of tissue development, stem cell maintenance, function, and differentiation. Articles were selected based on topic and requests from readers for full-text and PDF versions of the article. We hope you will enjoy this selection and look forward to your feedback (@JCellBiol).
Image © 2018 Casey et al.