Cell Division 2018

Mitosis and meiosis require the timely coordination of signaling cascades, membrane remodeling complexes, and cytoskeletal machineries to ensure the proper distribution and inheritance of genetic material, molecules, and organelles. Defects in this process result in important and diverse consequences, notably in the context of cancer and developmental disorders, illustrating the complexity of cell division and its regulation.

In this special collection, JCB Board member Rebecca Heald and Senior Scientific Editor Melina Casadio are bringing together a selection of recent, exciting developments in the field that were published in JCB. The collection is composed of papers our readers most downloaded and papers we editorially selected to represent the range of subfields relevant to cell division. We include primary research papers and review articles that delve into the crosstalk between motors, microtubules and signaling molecules during division, as well as manuscripts that examine the mechanisms by which cells ensure the faithful segregation of materials during meiosis or mitosis. Additional studies investigate how signaling cascades interact to regulate mitosis in response to nutrient availability and advance our mechanistic understanding of mitosis, meiosis, and cytokinesis. We hope you enjoy re-discovering these papers with us and look forward to your feedback on social media.

Keywords:

mitosis, actomyosin, spindle, septin, microtubule, centrosome, actin, kinetochore, centromere, meiosis, cell division, cytokinesis