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Cell Biology of Cancer 2018

Defining how cells malfunction in disease pathogenesis and pathology is foundational for clinical studies. To develop new therapeutic strategies against tumors, fundamental questions need to be addressed at the cellular level. What are the drivers of transformation, tumor growth, and metastasis? What defines the genetic, transcriptomic, and metabolic signatures of cancer cells? What is the impact of metabolism on the cell?s epigenetic landscape? What are the roles of mitochondria and autophagy in cancer, and the roles of the microenvironment in shaping the tumor? What controls the genomic (in)stability of tumor cells, their differentiation program and proliferative capacity?

Ahead of the annual meeting of the American Association for Cancer Research, the JCB Editorial team has assembled a special collection of recent, exciting JCB articles that explores recent advances in cancer biology. We focus this selection on epigenetics, genetics, signaling, metabolism, migration, and the interaction between the tumor and its microenvironment. We celebrate the progress made to understand the cell biology of tumors and look forward to the follow-up studies helping to bring these innovative, foundational results to patient care.

KEYWORDS:

tumor suppressor, invasion, tumorigenesis, epigenetics, metabolism, metastasis, cancer, migration, oncogene, signaling

Special Collection Image
Report
Monika Mis; Siobhan O’Brien; Zachary Steinhart; Sichun Lin; Traver Hart; Jason Moffat; Stephane Angers
DOI: 10.1083/jcb.201903017
Article
Dawid G. Nowak; Ksenya Cohen Katsenelson; Kaitlin E. Watrud; Muhan Chen; Grinu Mathew; Vincent D. D’Andrea; Matthew F. Lee; Manojit Mosur Swamynathan; Irene Casanova-Salas; Megan C. Jibilian; Caroline L. Buckholtz; Alexandra J. Ambrico; Chun-Hao Pan; John E. Wilkinson; Alexandra C. Newton; Lloyd C. Trotman
DOI: 10.1083/jcb.201902048
Article
Martina Zobel; Andrea Disanza; Francesca Senic-Matuglia; Michel Franco; Ivan Nicola Colaluca; Stefano Confalonieri; Sara Bisi; Elisa Barbieri; Giusi Caldieri; Sara Sigismund; Salvatore Pece; Philippe Chavrier; Pier Paolo Di Fiore; Giorgio Scita
DOI: 10.1083/jcb.201802023
Spotlight
Hyungsoo Kim; Ze’ev A. Ronai
DOI: 10.1083/jcb.201712007
Article
Ivan Nicola Colaluca; Andrea Basile; Lee Freiburger; Veronica D'Uva; Davide Disalvatore; Manuela Vecchi; Stefano Confalonieri; Daniela Tosoni; Valentina Cecatiello; Maria Grazia Malabarba; Chun-Jiun Yang; Masatsune Kainosho; Michael Sattler; Marina Mapelli; Marina Mapelli; Salvatore Pece; Salvatore Pece; Pier Paolo Di Fiore; Pier Paolo Di Fiore
DOI: 10.1083/jcb.201709092
Article
Manuel Viotti; Catherine Wilson; Mark McCleland; Hartmut Koeppen; Benjamin Haley; Suchit Jhunjhunwala; Christiaan Klijn; Zora Modrusan; David Arnott; Marie Classon; Jean-Philippe Stephan; Ira Mellman
DOI: 10.1083/jcb.201705031
Article
Ming-Xin An; Si Li; Han-Bing Yao; Chao Li; Jia-Mei Wang; Jia Sun; Xin-Yu Li; Xiao-Na Meng; Hua-Qin Wang
DOI: 10.1083/jcb.201701064
Article
Begum Erdogan; Begum Erdogan; Mingfang Ao; Lauren M. White; Anna L. Means; Bryson M. Brewer; Lijie Yang; M. Kay Washington; Chanjuan Shi; Omar E. Franco; Alissa M. Weaver; Simon W. Hayward; Deyu Li; Donna J. Webb
DOI: 10.1083/jcb.201704053
Correction
Jia Qu; Wenyi Sun; Jie Zhong; Hao Lv; Mingrui Zhu; Jun Xu; Nan Jin; Zuoquan Xie; Minjia Tan; Shu-Hai Lin; Meiyu Geng; Jian Ding; Min Huang
DOI: 10.1083/JCB.20160700807172017c
Spotlight
Catherine Rabouille
DOI: 10.1083/jcb.201706039
Article
Sang Bum Kim; Hye Rim Kim; Min Chul Park; Seongmin Cho; Peter C. Goughnour; Daeyoung Han; Ina Yoon; YounHa Kim; Taehee Kang; Eunjoo Song; Pilhan Kim; Hyosun Choi; Ji Young Mun; Chihong Song; Sangmin Lee; Hyun Suk Jung; Sunghoon Kim
DOI: 10.1083/jcb.201605118
Spotlight
Tomohiro Mizutani; Yoshiyuki Tsukamoto; Hans Clevers
DOI: 10.1083/jcb.201704014
Report
Pamela Riemer; Mattias Rydenfelt; Matthias Marks; Karen van Eunen; Kathrin Thedieck; Bernhard G. Herrmann; Nils Blüthgen; Christine Sers; Markus Morkel
DOI: 10.1083/jcb.201610058
Spotlight
Kenji Shimada; Susan M. Gasser
DOI: 10.1083/jcb.201701038
Article
Yi Liu; José Renato Cussiol; Diego Dibitetto; Jennie Rae Sims; Shyam Twayana; Robert Samuel Weiss; Raimundo Freire; Federica Marini; Achille Pellicioli; Marcus Bustamante Smolka; Marcus Bustamante Smolka
DOI: 10.1083/jcb.201607031
Article
Muhan Chen; Dawid G. Nowak; Navneet Narula; Brian Robinson; Kaitlin Watrud; Alexandra Ambrico; Tali M. Herzka; Martha E. Zeeman; Matthias Minderer; Wu Zheng; Saya H. Ebbesen; Kendra S. Plafker; Carlos Stahlhut; Victoria M.Y. Wang; Lorna Wills; Abu Nasar; Mireia Castillo-Martin; Carlos Cordon-Cardo; John E. Wilkinson; Scott Powers; Raffaella Sordella; Nasser K. Altorki; Vivek Mittal; Brendon M. Stiles; Scott M. Plafker; Lloyd C. Trotman
DOI: 10.1083/jcb.201604025
Spotlight
Nick R. Leslie
DOI: 10.1083/jcb.201612014
Article
Jia Qu; Wenyi Sun; Jie Zhong; Hao Lv; Mingrui Zhu; Jun Xu; Nan Jin; Zuoquan Xie; Minjia Tan; Shu-Hai Lin; Meiyu Geng; Jian Ding; Min Huang
DOI: 10.1083/jcb.201607008
Spotlight
Marcel A.T.M. van Vugt
DOI: 10.1083/jcb.201701026
Report
Ryan J. Petrie; Heather M. Harlin; Lulu I T. Korsak; Kenneth M. Yamada
DOI: 10.1083/jcb.201605097
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