Cancer Cell Biology 2019
To coincide with the 2019 AACR Annual Meeting, we are delighted to share exciting discoveries across the spectrum of cancer research recently published in JCB. This collection celebrates works that advance our understanding of the fundamental molecular and cellular events shaping tumors and that suggest novel potential therapeutic avenues, reflecting JCB’s scope and interest in cancer research—from core mechanistic findings to translational studies. Learn about wide-ranging -omics studies identifying progenitor cell vulnerabilities that could be targeted in chemo-prevention, as well as works teasing out the determinants of transformation, invasion, and dissemination. Explore analyses that define the biomechanics of invasive behavior and that dissect the genetic changes driving tumorigenesis. Read about the mechanisms by which cancer cells co-opt cellular pathways to enhance growth signals.
Our interest in translational cell biology is further highlighted through our new Inside Look series, which illustrates how cell biology can be harnessed in the clinic. Important studies of cell division and T cell signaling have paved the way for current anti-mitotic therapies and immune checkpoint blockade drugs, two topics detailed in Inside Looks.
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