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Cancer Cell Biology 2019

To coincide with the 2019 AACR Annual Meeting, we are delighted to share exciting discoveries across the spectrum of cancer research recently published in JCB. This collection celebrates works that advance our understanding of the fundamental molecular and cellular events shaping tumors and that suggest novel potential therapeutic avenues, reflecting JCB’s scope and interest in cancer research—from core mechanistic findings to translational studies. Learn about wide-ranging -omics studies identifying progenitor cell vulnerabilities that could be targeted in chemo-prevention, as well as works teasing out the determinants of transformation, invasion, and dissemination. Explore analyses that define the biomechanics of invasive behavior and that dissect the genetic changes driving tumorigenesis. Read about the mechanisms by which cancer cells co-opt cellular pathways to enhance growth signals.

Our interest in translational cell biology is further highlighted through our new Inside Look series, which illustrates how cell biology can be harnessed in the clinic. Important studies of cell division and T cell signaling have paved the way for current anti-mitotic therapies and immune checkpoint blockade drugs, two topics detailed in Inside Looks.

Connect with JCB with any feedback or questions and check our homepage to subscribe to our table of contents.

Image Credit: iStock.com/rightdx

Special Collection Image
Inside Look
Enfu Hui
DOI: 10.1083/jcb.201810035
Inside Look
Julia Tischer; Fanni Gergely
DOI: 10.1083/jcb.201808077
Report
Orit Katarina Sirka; Eliah R. Shamir; Andrew J. Ewald
DOI: 10.1083/jcb.201802144
Article
Rocío G. Sampayo; Andrés M. Toscani; Matthew G. Rubashkin; Kate Thi; Luciano A. Masullo; Ianina L. Violi; Jonathon N. Lakins; Alfredo Cáceres; William C. Hines; Federico Coluccio Leskow; Fernando D. Stefani; Dante R. Chialvo; Mina J. Bissell; Valerie M. Weaver; Marina Simian
DOI: 10.1083/jcb.201703037
Article
Scott R. Frank; Clemens P. Köllmann; Phi Luong; Giorgio G. Galli; Lihua Zou; André Bernards; Gad Getz; Raffaele A. Calogero; Morten Frödin; Steen H. Hansen
DOI: 10.1083/jcb.201710058
Article
Scott W. Messenger; Sang Su Woo; Zhongze Sun; Thomas F.J. Martin
DOI: 10.1083/jcb.201710132
Tools
Alison E. Casey; Ankit Sinha; Rajat Singhania; Julie Livingstone; Paul Waterhouse; Pirashaanthy Tharmapalan; Jennifer Cruickshank; Mona Shehata; Erik Drysdale; Hui Fang; Hyeyeon Kim; Ruth Isserlin; Swneke Bailey; Tiago Medina; Genevieve Deblois; Yu-Jia Shiah; Dalia Barsyte-Lovejoy; Stefan Hofer; Gary Bader; Mathieu Lupien; Cheryl Arrowsmith; Stefan Knapp; Daniel De Carvalho; Hal Berman; Paul C. Boutros; Thomas Kislinger; Rama Khokha
DOI: 10.1083/jcb.201804042
Report
Carla A.M. Lopes; Carla A.M. Lopes; Marta Mesquita; Ana Isabel Cunha; Joana Cardoso; Sara Carapeta; Cátia Laranjeira; António E. Pinto; José B. Pereira-Leal; António Dias-Pereira; Mónica Bettencourt-Dias; Mónica Bettencourt-Dias; Paula Chaves; Paula Chaves
DOI: 10.1083/jcb.201711191
Article
Tim B. Fessenden; Yvonne Beckham; Mathew Perez-Neut; Guillermina Ramirez-San Juan; Aparajita H. Chourasia; Kay F. Macleod; Patrick W. Oakes; Margaret L. Gardel
DOI: 10.1083/jcb.201703145
Article
Alexander D. Rhys; Pedro Monteiro; Christopher Smith; Malti Vaghela; Teresa Arnandis; Takuya Kato; Birgit Leitinger; Erik Sahai; Andrew McAinsh; Guillaume Charras; Susana A. Godinho
DOI: 10.1083/jcb.201704102
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