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Autophagy 2019

Autophagy is an essential homeostatic process at the interface of membrane trafficking, quality control, the immune response, and metabolism. Fundamental analyses of the autophagic process are needed to guide investigations of the role and regulation of autophagy in aging and diseases such as neurodegeneration, cancer, infection and immunity, inflammation and allergy, and metabolic diseases. In this special collection, JCB Board member Hong Zhang and Senior Scientific Editor Melina Casadio revisit some of the most exciting articles recently published in JCB that advance our understanding of the mechanisms and disease relevance of autophagy. Papers were selected based on topic and number of reader requests for the full-text and PDF versions of the article. We hope you enjoy this special collection and look forward to your feedback on (https://twitter.com/JCellBiol)Twitter and (https://www.facebook.com/JCellBiol)Facebook.

Image © 2018 Zhao and Zhang: Overview of the autophagy pathway. Autophagosomes are generated at PI(3)P-enriched subdomains of the ER, called omegasomes (Ω). A cup-shaped autophagosomal precursor structure, the IM, forms in close association with the omegasome. Upon closure of the IM, cytoplasmic contents are enclosed in double-membrane autophagosomes, also known as AVi. Autophagosomes undergo a series of fusion processes with various endolysosomal compartments, including the earliest vesicular endocytic vesicles (EVE), early endosomes (EE), MVBs, and LEs/lysosomes to form amphisomes, also known as AVi/d. Amphisomes finally mature into functional autolysosomes, also called AVd.(p)

KEYWORDS

Lysosome, Metabolism, Infection, Immunity, ATG, SNARE, Autophagy, Membrane trafficking, Autophagosome, Mitophagy

Special Collection Image
Article
Aykut Turan; Linda Grosche; Adalbert Krawczyk; Petra Mühl-Zürbes; Christina Drassner; Alexandra Düthorn; Mirko Kummer; Mike Hasenberg; Sylvia Voortmann; Holger Jastrow; Jan Dörrie; Niels Schaft; Max Kraner; Katinka Döhner; Beate Sodeik; Alexander Steinkasserer; Christiane Silke Heilingloh
DOI: 10.1083/jcb.201801151
Review
Yan G. Zhao; Hong Zhang
DOI: 10.1083/jcb.201810099
Article
Nitin Mohan; Elena M. Sorokina; Ione Vilanova Verdeny; Angel Sandoval Alvarez; Melike Lakadamyali
DOI: 10.1083/jcb.201807124
Article
Levent Bas; Daniel Papinski; Mariya Licheva; Raffaela Torggler; Sabrina Rohringer; Martina Schuschnig; Claudine Kraft
DOI: 10.1083/jcb.201804028
Article
Jieqiong Gao; Fulvio Reggiori; Christian Ungermann
DOI: 10.1083/jcb.201804039
Report
Keigo Morita; Yutaro Hama; Tamaki Izume; Norito Tamura; Toshihide Ueno; Yoshihiro Yamashita; Yuriko Sakamaki; Kaito Mimura; Hideaki Morishita; Wataru Shihoya; Osamu Nureki; Hiroyuki Mano; Noboru Mizushima
DOI: 10.1083/jcb.201804132
Article
Jakob Mejlvang; Hallvard Olsvik; Steingrim Svenning; Jack-Ansgar Bruun; Yakubu Princely Abudu; Kenneth Bowitz Larsen; Andreas Brech; Tom E. Hansen; Hanne Brenne; Terkel Hansen; Harald Stenmark; Terje Johansen
DOI: 10.1083/jcb.201711002
Article
Md. Golam Mostofa; Muhammad Arifur Rahman; Naoki Koike; Akter MST Yeasmin; Nafisa Islam; Talukdar Muhammad Waliullah; Shun Hosoyamada; Mitsugu Shimobayashi; Takehiko Kobayashi; Michael N. Hall; Takashi Ushimaru
DOI: 10.1083/jcb.201706164
Article
Rubén Gómez-Sánchez; Jaqueline Rose; Rodrigo Guimarães; Muriel Mari; Daniel Papinski; Ester Rieter; Willie J. Geerts; Ralph Hardenberg; Claudine Kraft; Christian Ungermann; Fulvio Reggiori
DOI: 10.1083/jcb.201710116
Report
Takahide Matsui; Peidu Jiang; Saori Nakano; Yuriko Sakamaki; Hayashi Yamamoto; Noboru Mizushima
DOI: 10.1083/jcb.201712058
Report
Tânia Catarina Medeiros; Ryan Lee Thomas; Ruben Ghillebert; Martin Graef
DOI: 10.1083/jcb.201801168
Report
Sho W. Suzuki; Scott D. Emr
DOI: 10.1083/jcb.201709162
Report
Juliette J. Lee; Alvaro Sanchez-Martinez; Aitor Martinez Zarate; Cristiane Benincá; Ugo Mayor; Michael J. Clague; Alexander J. Whitworth
DOI: 10.1083/jcb.201801044
Article
Suresh Kumar; Ashish Jain; Farzin Farzam; Jingyue Jia; Yuexi Gu; Seong Won Choi; Michal H. Mudd; Aurore Claude-Taupin; Michael J. Wester; Keith A. Lidke; Tor-Erik Rusten; Vojo Deretic
DOI: 10.1083/jcb.201708039
Article
Jonathon L. Burman; Sarah Pickles; Chunxin Wang; Shiori Sekine; Jose Norberto S. Vargas; Zhe Zhang; Alice M. Youle; Catherine L. Nezich; Xufeng Wu; John A. Hammer; Richard J. Youle
DOI: 10.1083/jcb.201612106
Report
Péter Lőrincz; Sarolta Tóth; Péter Benkő; Zsolt Lakatos; Attila Boda; Gábor Glatz; Martina Zobel; Sara Bisi; Krisztina Hegedűs; Szabolcs Takáts; Giorgio Scita; Gábor Juhász
DOI: 10.1083/jcb.201611027
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