Structural Biology 2021
Advances in technologies that probe the ultrastructure of cells, organelles, and proteins—including developments in cryo-electron microscopy and volume electron microscopy—are allowing cell biologists to gain new knowledge about the organization of proteins and protein complexes with increased structural resolution, providing new insights into fundamental questions in cell biology. In this collection, we explore how such novel structural information deepens our understanding of nuclear membrane organization after fertilization, cytoskeletal organization, autophagy machinery organization, lipid transfer, exocytic vesicle tethering and fusion with the plasma membrane, how disease-linked mutations affect the function of a membrane fusion regulator, and more. This wide-ranging selection illustrates the breadth of insight newly accessible thanks to structural biology methods and includes cutting-edge applications of cryo-EM technology and in situ structural biology techniques to study disease and developmental processes. We look forward to seeing how cell and structural biologists collaborate to drive innovation and reach new depths of cell biological understanding in the future.
Image © Jyrki Hokkanen, CSC—IT Center for Science, Espoo, Finland