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Special Collection of Reviews on Cancer Cell Biology

We are pleased to present this collection of reviews on the cell biology of cancer. Basic science provides the foundation for progress in cancer biology, and we are delighted to highlight reviews discussing fundamental cell biological discoveries and how these latest advances can be harnessed therapeutically for translational development. Learn about the cellular mechanisms protecting genome stability at sites of stalled DNA replication. Read about the relationship between signaling and endocytosis in cancer, and how this can enhance cancer cell survival, migration, and proliferation. Tumor tissues exhibit altered mechanical properties - learn about the role of mechanotransduction in the activation of tumorigenic pathways and how cancer cells use both proteolytic and physical mechanisms to invade the basement membrane during cancer progression. Perturbations in cellular metabolism are ubiquitous in cancer - read about the role of one-carbon metabolism in tumorigenesis and strategies to block glutathione synthesis and utilization pathways to inhibit tumor propagation and treatment resistance, as well as the impact of metabolites on gene expression programs that promote malignancy. Finally, get an overview of immune checkpoint inhibitors and anti-mitotic therapies in cancer with posters from our Inside Look series.

We hope you enjoy this collection and look forward to your feedback on Facebook and Twitter.

Image © Elizabeth Harper

Special Collection Image
Review
Miguel Reina-Campos; Maria T. Diaz-Meco; Jorge Moscat
DOI: 10.1083/jcb.201907022
Review
Julie Chang; Ovijit Chaudhuri
DOI: 10.1083/jcb.201903066
Inside Look
Enfu Hui
DOI: 10.1083/jcb.201810035
Review
Kimberly Rickman; Agata Smogorzewska
DOI: 10.1083/jcb.201809012
Inside Look
Julia Tischer; Fanni Gergely
DOI: 10.1083/jcb.201808077
Review
Ankita Bansal; M. Celeste Simon
DOI: 10.1083/jcb.201804161
Review
Juan Manuel Schvartzman; Craig B. Thompson; Lydia W.S. Finley
DOI: 10.1083/jcb.201803061
Review
Florence Broders-Bondon; Thanh Huong Nguyen Ho-Bouldoires; Maria-Elena Fernandez-Sanchez; Emmanuel Farge; Emmanuel Farge
DOI: 10.1083/jcb.201701039
Perspective
Sandra L. Schmid
DOI: 10.1083/jcb.201705017
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