The reappearance of beta-adrenergic receptors in C6-glioma cells after desensitization with isoproterenol was studied using the antagonist [3H]CGP-12177. Reappearance had the following properties: (a) it occurred in intact cells only, (b) it was temperature dependent, (c) it required an Na+/H+ gradient, low intracellular Ca2+ activity, and (d) it required ATP, and (e) intact lysosomes. The results suggest endocytosis and recycling of the beta-adrenergic receptor after agonist treatment.
Article| November 01 1983
Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells.
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1983) 97 (5): 1538–1543.
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C Hertel, M Staehelin; Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells.. J Cell Biol 1 November 1983; 97 (5): 1538–1543. doi: https://doi.org/10.1083/jcb.97.5.1538
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