Eucaryotic endoplasmic reticulum and bacterial inner cell membranes use strikingly similar mechanisms to transport proteins from one cellular compartment to another. Using a mammalian linked transcription-translation system, we show here that canine pancreatic microsomes accurately cleave off the signal sequence of β-lactamase, a secreted bacterial protein. We suggest that the apparent differences between bacterial and eukaryotic protein transport may involve only minor modulations of a profoundly conserved mechanism.
Article| April 01 1983
Transport and cleavage of bacterial pre-β-lactamase by mammalian microsomes
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1983) 96 (4): 1117–1119.
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HM Kronenberg, BJ Fennick, TJ Vasicek; Transport and cleavage of bacterial pre-β-lactamase by mammalian microsomes . J Cell Biol 1 April 1983; 96 (4): 1117–1119. doi: https://doi.org/10.1083/jcb.96.4.1117
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