The light and, to a lesser extent, the dark cells of the cortical collecting tubules in mouse kidney contain a great number of granules which according to histochemical tests are composed of phospholipids and proteins. These granules are bounded by a triple-layered membrane measuring approximately 75 A across, and contain one or several crystals with a hexagonal or square lattice. These crystals are built up of rod-shaped units, which appear dense after osmium fixation, measure about 48 A in diameter, and are separated by a light interspace of similar dimensions. The mean center-to-center distance of the rods is about 96 A. The structure is explained as a lipoprotein crystallized within a membrane-bounded vacuole. No relationship between these granules and mitochondria was found. The physiological significance of the granules remains unknown.
Article| January 01 1961
LIPOPROTEIN GRANULES IN THE CORTICAL COLLECTING TUBULES OF MOUSE KIDNEY
From The Rockefeller Institute. Dr. Miller is a Fellow of The Rockefeller Foundation, on leave of absence from Pathologisches Institut der Universität, Innsbruck, Austria
Received: June 02 1960
Copyright, 1961, by The Rockefeller Institute Press
Fritz Miller; LIPOPROTEIN GRANULES IN THE CORTICAL COLLECTING TUBULES OF MOUSE KIDNEY . J Biophys and Biochem Cytol 1 January 1961; 9 (1): 157–170. doi: https://doi.org/10.1083/jcb.9.1.157
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