The extent of coordinate control over the multiple initiation events in DNA replication has been investigated in three mammalian cell lines by DNA fiber autoradiography. Quantitative estimates have been obtained of the degree of synchrony among initiations occurring on stretches of DNA. Synchrony decreases markedly with increasing distance between initiation sites in MDBK (bovine) and L929 (mouse) cells, but only slightly in muntjac cells. Possible control mechanisms for the initiation process are discussed.
Article| June 01 1979
Temporal organization of replication in DNA fibers of mammalian cells.
B R Jasny
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1979) 81 (3): 692–697.
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B R Jasny, I Tamm; Temporal organization of replication in DNA fibers of mammalian cells.. J Cell Biol 1 June 1979; 81 (3): 692–697. doi: https://doi.org/10.1083/jcb.81.3.692
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