The major proteins in isolated synaptic junctions (SJs) and postsynaptic densities (PSDs) have been compared to actin, tubulin, and the major neurofilament (NF) protein by two-dimensional gel electrophoresis and tryptic peptide map analysis. These studies show: (a) tubulin is present in SJ and PSD fractions and is identical to cytoplasmic tubulin, (b) actin in these fractions is very similar to the gamma- and beta-actin found predominantly in nonmuscle cells, and (c) the major PSD protein is distinct from all other known fibrous proteins.
Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide.
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P T Kelly, C W Cotman; Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide.. J Cell Biol 1 October 1978; 79 (1): 173–183. doi: https://doi.org/10.1083/jcb.79.1.173
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