Receptor cells in the ear are excited through the bending of sensory hairs which project in a bundle from their surface. The individual stereocilia of a bundle contain filaments about 5 nm in diameter. The identity of these filaments has been investigated in the crista ampullaris of the frog and guinea pig by a technique of decoration with subfragment-1 of myosin (S-1). After demembranation with Triton X-100 and incubation with S-1, "arrowhead" formation was observed along the filaments of the stereocilia and their rootlets and also along filaments in the cuticular plate inside the receptor cell. The distance between attached S-1 was 35 nm and arrowheads pointed in towards the cell soma. It is concluded that the filaments of stereocilia are composed of actin.
Article| November 01 1977
Actin filaments in sensory hairs of inner ear receptor cells.
H C Cheung
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1977) 75 (2): 339–343.
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A Flock, H C Cheung; Actin filaments in sensory hairs of inner ear receptor cells.. J Cell Biol 1 November 1977; 75 (2): 339–343. doi: https://doi.org/10.1083/jcb.75.2.339
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