Mouse beta-glucuronidase has a dual intracellular localization, being present in both endoplasmic reticulum and lysosomes of several tissues. Previous studies demonstrated that the protein egasyn is complexed with microsomal but not lysosomal glucuronidase and that a mutant lacking egasyn is deficient in microsomal, but not lysosomal, glucuronidase. By means of a recently developed radioimmunoassay for egasyn, the relationship between microsomal glucuronidase levels and egasyn levels has been examined in various adult tissues, during postnatal development in liver, and after androgen induction of glucuronidase in kidney. The results indicate that the relative availability of egasyn determines the balance between glucuronidase incorporation into membranes and that into lysosomes.
Article| June 01 1977
Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues.
A J Lusis
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1977) 73 (3): 728–735.
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A J Lusis, K Paigen; Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues.. J Cell Biol 1 June 1977; 73 (3): 728–735. doi: https://doi.org/10.1083/jcb.73.3.728
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