The chronic administration of phalloidin induces an extensive development of tight junctions between rat hepatocytes. The junctional strands lose their predominantly parallel orientation with respect to the canalicular lumen and extend abluminally in irregular patterns which cover large membrane areas at considerable distance from the bile canaliculi. These changes indicate both proliferation and provide further evidence that these junctions are not permanent differentiations of the cell membrane.
Article| March 01 1976
In vivo induction of tight junction proliferation in rat liver.
Online Issn: 1540-8140
Print Issn: 0021-9525
J Cell Biol (1976) 68 (3): 793–798.
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R Montesano, G Gabbiani, A Perrelet, L Orci; In vivo induction of tight junction proliferation in rat liver.. J Cell Biol 1 March 1976; 68 (3): 793–798. doi: https://doi.org/10.1083/jcb.68.3.793
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