Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained markedly enhanced numbers of microtubules and discharged peroxidase-negative (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme from specific granules was dose and time dependent, could be inhibitied by alpha-methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were associated with internalized plasma membrane bearing Con A binding sites.
Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes.
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S Hoffstein, R Soberman, I Goldstein, G Weissmann; Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes.. J Cell Biol 1 March 1976; 68 (3): 781–787. doi: https://doi.org/10.1083/jcb.68.3.781
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