There are multiple TB resistance pathways in the cell.
KIRSCHNER/NAS
Two inhibition classes served distinct time frames: effects were immediate for inhibition of antigen processing or peptide loading but delayed for inhibition of MHC transcription or maturation. The long pulses of IFN-γ used by two previous groups resulted in inhibition mediated primarily by effects on either maturation or transcription, respectively, with some part of the effect unexplained.
To suggest candidates for these unexplained effects, Kirschner and colleagues identified a number of processes whose inhibition in silico has major effects on antigen presentation efficiency. In vitro time series will allow many of the model's predictions to be tested.
Reference:
Chang, S.T., et al. 2005. Proc. Natl. Acad. Sci. USA. doi:
The Rockefeller University Press
2005