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Volume 158, Issue 3
5 August 2002
Journal of Cell Biology Cover Image for Volume 158, Issue 3
Review| August 05 2002

Hijacking the translation apparatus by RNA viruses

Martin Bushell,
Martin Bushell
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305
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Peter Sarnow
Peter Sarnow
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305
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Author and Article Information
Martin Bushell
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305
Peter Sarnow
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305
Address correspondence to Peter Sarnow, Dept. of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305. Tel.: (650) 498-7076. Fax: (650) 498-7147. E-mail: [email protected]
*

Abbreviations used in this paper: eIF, eukaryotic initiation factor; EMCV, encephalomyocarditis virus; GDP, guanosine 5′-diphosphate; IGR, intergenic region; IRES, internal ribosome entry site; tRNAiMet, initiator tRNA-methionine; PABP, polyadenosine binding protein.

Received: May 10 2002
Revision Received: June 13 2002
Accepted: June 17 2002
Online ISSN: 1540-8140
Print ISSN: 0021-9525
The Rockefeller University Press
2002
J Cell Biol (2002) 158 (3): 395–399.
https://doi.org/10.1083/jcb.200205044
Article history
Received:
May 10 2002
Revision Received:
June 13 2002
Accepted:
June 17 2002

As invading viruses do not harbor functional ribosomes in their virions, successful amplification of the viral genomes requires that viral mRNAs compete with cellular mRNAs for the host cell translation apparatus. Several RNA viruses have evolved remarkable strategies to recruit the host translation initiation factors required for the first steps in translation initiation by host cell mRNAs. This review describes the ways that three families of RNA viruses effectively usurp limiting translation initiation factors from the host.

The Rockefeller University Press
2002
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