Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins

Papp , S.; Dziak , E.; Michalak , M.; Opas , M.

doi:10.1083/jcb.200207136

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Review| February 18 2003

Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca²⁺-handling proteins

S. Papp,

E. Dziak,

M. Michalak,

M. Opas

Author and Article Information

S. Papp

1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8

E. Dziak

1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8

M. Michalak

2Canadian Institutes of Health Research, Membrane Protein Research Group, and the Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

M. Opas

1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8

Address correspondence to S. Papp, Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8. Tel.: (416) 978-8947. E-mail: [email protected]

*

Abbreviations used in this paper: InsP₃, inositol 1,4,5-trisphosphate; PDI, protein disulfide isomerase; SERCA, sarcoplasmic/endoplasmic reticulum Ca²⁺-transporting ATPase.

Received: July 24 2002

Revision Received: January 14 2003

Accepted: January 15 2003

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2003

J Cell Biol (2003) 160 (4): 475–479.

https://doi.org/10.1083/jcb.200207136

The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca²⁺-handling proteins, namely the Ca²⁺-binding proteins, the Ca²⁺ pumps and the Ca²⁺ release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca²⁺ signals, Ca²⁺ homeostasis, and protein folding and quality control.

The Rockefeller University Press

2003

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Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca²⁺-handling proteins