A new view of the spindle checkpoint

Hoyt , M. Andrew

doi:10.1083/jcb.200108010

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Spotlight| September 03 2001

A new view of the spindle checkpoint

M. Andrew Hoyt

Author and Article Information

M. Andrew Hoyt

Department of Biology, The Johns Hopkins University, Baltimore, MD 21218

Address correspondence to M. Andrew Hoyt, Dept. of Biology, Mudd Hall, Rm. 36, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218. Tel.: (410) 516-7299. Fax: (410) 516- 5213. E-mail: [email protected]

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Abbreviations used in this paper: APC, anaphase-promoting complex; MCC, mitogen checkpoint complex.

Received: August 01 2001

Accepted: August 10 2001

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2001

J Cell Biol (2001) 154 (5): 909–912.

https://doi.org/10.1083/jcb.200108010

Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.

The Rockefeller University Press

2001

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