The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse.
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.
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G Tanigawa, L Orci, M Amherdt, M Ravazzola, J B Helms, J E Rothman; Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.. J Cell Biol 15 December 1993; 123 (6): 1365–1371. doi: https://doi.org/10.1083/jcb.123.6.1365
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