After 10 days of a protein-free diet the acinar cells of the rat pancreas showed a coarsening of nuclear matrix, depletion of zymogen granules, some loss of ribosomes, and a widening of the spaces between ergastoplasmic membranes. In addition, there could be found, but rarely, a lesion of the ergastoplasm consisting of vacuoles of agranular, disoriented membranes, which was similar to a lesion produced by ethionine. Thereafter, a return toward normal structure occurred which was characterized by beginning increase in the size of the Golgi apparatus at 12 days, appearance of zymogen granules at 18 days, and a relatively normal appearing but smaller cell at 28 days. After 10 to 12 days of protein deprivation a reversal of many of the morphologic effects of protein deprivation was accompanied by a return toward normal of some pancreatic enzyme activities. Possibly this spontaneous return toward normal levels represented a raiding of protein stores, or it may have been an adaptive phenomenon.
Article|
February 01 1962
CHANGES IN PANCREATIC ACINAR CELLS DURING PROTEIN DEPRIVATION
Bernard Weisblum,
Bernard Weisblum
From the Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn
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Lawrence Herman,
Lawrence Herman
From the Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn
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Patrick J. Fitzgerald
Patrick J. Fitzgerald
From the Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn
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Bernard Weisblum
From the Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn
Lawrence Herman
From the Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn
Patrick J. Fitzgerald
From the Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn
Received:
July 02 1961
Online ISSN: 1540-8140
Print ISSN: 0021-9525
Copyright, 1962, by The Rockefeller Institute Press
1962
J Cell Biol (1962) 12 (2): 313–327.
Article history
Received:
July 02 1961
Citation
Bernard Weisblum, Lawrence Herman, Patrick J. Fitzgerald; CHANGES IN PANCREATIC ACINAR CELLS DURING PROTEIN DEPRIVATION . J Cell Biol 1 February 1962; 12 (2): 313–327. doi: https://doi.org/10.1083/jcb.12.2.313
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