Sexual adhesion between Chlamydomonas reinhardtii gametes elicits a rise in intracellular cAMP levels, and exogenous elevation of intracellular cAMP levels in gametes of a single mating type induces such mating responses as cell wall loss, flagellar tip activation, and mating structure activation (Pasquale, S. M., and U. W. Goodenough. 1987. J. Cell Biol. 105:2279-2292). Here evidence is presented that sexual adhesion mobilizes agglutinin to the flagellar surface, and that this mobilization can be induced by exogenous presentation of cAMP to gametes of a single mating type. It is proposed that Chlamydomonas adhesion entails a positive feedback system--initial contacts stimulate the presentation of additional agglutinin--and that this feedback is mediated by adhesion-induced cAMP generation.
Article| July 01 1989
Cyclic AMP enhances the sexual agglutinability of Chlamydomonas flagella.
U W Goodenough
Department of Biology, Washington University, St. Louis, Missouri 63130.
Online ISSN: 1540-8140
Print ISSN: 0021-9525
J Cell Biol (1989) 109 (1): 247–252.
U W Goodenough; Cyclic AMP enhances the sexual agglutinability of Chlamydomonas flagella.. J Cell Biol 1 July 1989; 109 (1): 247–252. doi: https://doi.org/10.1083/jcb.109.1.247
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