The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.
Article| February 01 1989
The scanning model for translation: an update.
Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
Online ISSN: 1540-8140
Print ISSN: 0021-9525
J Cell Biol (1989) 108 (2): 229–241.
M Kozak; The scanning model for translation: an update.. J Cell Biol 1 February 1989; 108 (2): 229–241. doi: https://doi.org/10.1083/jcb.108.2.229
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