Various biological activities have been attributed to actin-capping proteins based on their in vitro effects on actin filaments. However, there is little direct evidence for their in vivo activities. In this paper, we show that Cap Z(36/32), a barbed end, actin-capping protein isolated from muscle (Casella, J. F., D. J. Maack, and S. Lin, 1986, J. Biol. Chem., 261:10915-10921) is localized to the barbed ends of actin filaments by electron microscopy and to the Z-line of chicken skeletal muscle by indirect immunofluorescence and electron microscopy. Since actin filaments associate with the Z-line at their barbed ends, these findings suggest that Cap Z(36/32) may play a role in regulating length, orienting, or attaching actin filaments to Z-discs.
Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle.
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J F Casella, S W Craig, D J Maack, A E Brown; Cap Z(36/32), a barbed end actin-capping protein, is a component of the Z-line of skeletal muscle.. J Cell Biol 1 July 1987; 105 (1): 371–379. doi: https://doi.org/10.1083/jcb.105.1.371
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