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Online ISSN: 1540-8140

Print ISSN: 0021-9525

2001

The Rockefeller University Press

J Cell Biol (2001) 152 (2): 421–422.

https://doi.org/10.1083/jcb.152.2.421

Table 1

Tight Junction Proteins

TJ proteins	Structural features	Function	Known partners
Claudins	4 TM, COOH-YV	TJ barrier	ZO-1¹
Occludin	4 TM	TJ barrier	ZO-1, ZO-2, Vap33, actin^1–3
JAM	1 TM, Ig-like	Monocyte transmigration⁴
ZO-1	3 PDZ, 1SH3, GUK	Scaffold protein, signaling molecule	Occludin, claudins, ZO-2, -3, cingulin, actin, ZONAB^1,2,5,6
ZO-2	3 PDZ, 1SH3, GUK	Scaffold protein	ZO-1, actin²
ZO-3	3 PDZ, 1SH3, GUK	Scaffold protein	ZO-1, occludin²
AF-6	PDZ	Scaffold protein	Ras, ZO-1⁷
Dlg (Drosophila)	3 PDZ, 1SH3, GUK	Scaffold protein, signaling molecule⁸
Scribble (Drosophila)	4 PDZ	Fence/membrane traffic⁹
Cingulin	coiled coil		ZO-1, -2, -3, occludin, myosin⁵
Symplekin		Signaling molecule¹⁰
ASIP/Par3	3 PDZ	Signaling molecule	PKC ζ^11,12,13
Rab3b	GDP/GTP binding	Membrane traffic¹⁴
Rab13	GDP/GTP binding	Membrane traffic	δ-PDE^15,16
Rab8	GDP/GTP binding	Membrane traffic	G/C kinase^17,18
Sec6, Sec8		Vesicle docking	Exocyst subunits¹⁹

TJ proteins	Structural features	Function	Known partners
Claudins	4 TM, COOH-YV	TJ barrier	ZO-1¹
Occludin	4 TM	TJ barrier	ZO-1, ZO-2, Vap33, actin^1–3
JAM	1 TM, Ig-like	Monocyte transmigration⁴
ZO-1	3 PDZ, 1SH3, GUK	Scaffold protein, signaling molecule	Occludin, claudins, ZO-2, -3, cingulin, actin, ZONAB^1,2,5,6
ZO-2	3 PDZ, 1SH3, GUK	Scaffold protein	ZO-1, actin²
ZO-3	3 PDZ, 1SH3, GUK	Scaffold protein	ZO-1, occludin²
AF-6	PDZ	Scaffold protein	Ras, ZO-1⁷
Dlg (Drosophila)	3 PDZ, 1SH3, GUK	Scaffold protein, signaling molecule⁸
Scribble (Drosophila)	4 PDZ	Fence/membrane traffic⁹
Cingulin	coiled coil		ZO-1, -2, -3, occludin, myosin⁵
Symplekin		Signaling molecule¹⁰
ASIP/Par3	3 PDZ	Signaling molecule	PKC ζ^11,12,13
Rab3b	GDP/GTP binding	Membrane traffic¹⁴
Rab13	GDP/GTP binding	Membrane traffic	δ-PDE^15,16
Rab8	GDP/GTP binding	Membrane traffic	G/C kinase^17,18
Sec6, Sec8		Vesicle docking	Exocyst subunits¹⁹

Exponent numbers indicate references: 1, Itoh et al., 1999; 2, Wittchen et al., 1999; 3, Lapierre et al., 1999; 4, Martin-Padura et al., 1998; 5, Cordenonsi et al., 1999; 6, Balda and Matter, 2000; 7, Yamamoto et al., 1997; 8, Woods and Bryant, 1991; 9, Bilder and Perrimon, 2000a; 10, Keon et al., 1996; 11, Joberty et al., 2000; 12, Lin et al., 2000; 13, Izumi et al., 1998; 14, Weber et al., 1994; 15, Zahraoui et al., 1994; 16, Marzesco et al., 1998; 17, Huber et al., 1993; 18, Ren et al., 1996; and 19, Grindstaff et al., 1998.

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