ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS II. Ultrastructure of the Beta Granule

Greider , Marie H.; Howell , S. L.; Lacy , P. E.

doi:10.1083/jcb.41.1.162

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Article| April 01 1969

ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS : II. Ultrastructure of the Beta Granule

Marie H. Greider,

Marie H. Greider

From the Department of Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110.

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S. L. Howell,

S. L. Howell

From the Department of Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110.

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P. E. Lacy

From the Department of Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110.

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Author and Article Information

Marie H. Greider

From the Department of Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110.

S. L. Howell

From the Department of Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110.

P. E. Lacy

From the Department of Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110.

Dr. Howell's present address is the School of Biological Sciences, University of Sussex, Brighton, England

Received: August 23 1968

Revision Received: November 07 1968

Online ISSN: 1540-8140

Print ISSN: 0021-9525

1969

J Cell Biol (1969) 41 (1): 162–166.

https://doi.org/10.1083/jcb.41.1.162

Beta granules isolated from rat islets of Langerhans and subjected only to phosphotungstic acid had, in negatively stained images, a 50-A periodicity. This periodicity was also observed in thin-section profiles of beta granules in intact cells. In shadowed preparations, the granules were spherical in shape and had irregular edges and surface structure. The presence of such a periodicity in the beta granule indicates that its matrix may be composed of a crystalline material.

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ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS : II. Ultrastructure of the Beta Granule

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