Yersinia type III secretion send in the effectors

Cornelis , Guy R.

doi:10.1083/jcb.200205077

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Review| August 05 2002

Yersinia type III secretion : send in the effectors

Guy R. Cornelis

1Biozentrum der Universität Basel, CH-4056 Basel, Switzerland

2Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B 1200 Brussels, Belgium

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Author and Article Information

Guy R. Cornelis

1Biozentrum der Universität Basel, CH-4056 Basel, Switzerland

2Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B 1200 Brussels, Belgium

Address correspondence to Guy R. Cornelis, Biozentrum der Universität Basel, Klingelbergstr. 50-70, CH-4056 Basel, Switzerland. Tel.: 41-61-267-21-10. Fax: 41-61-267-21-18. E-mail: [email protected]

*

Abbreviations used in this paper: GAP, GTPase-activating protein; MKK, MAPK kinase; TTSS, type III secretion system.

Received: May 14 2002

Revision Received: June 24 2002

Accepted: July 09 2002

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2002

J Cell Biol (2002) 158 (3): 401–408.

https://doi.org/10.1083/jcb.200205077

Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block the cells' response to infection. Understanding the molecular mechanisms of this system has provided insight into the processes of phagocytosis and inflammation.

The Rockefeller University Press

2002

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