GROWTH INHIBITION OF MURINE TUMOR CELLS, IN VITRO, BY PUROMYCIN, [6N]O2'-DIBUTYRYL 3',5'-ADENOSINE MONOPHOSPHATE, OR ADENOSINE Evidence of Commitment for Cell Division

Thomas , D. B.; Medley , Gay; Lingwood , C. A.

doi:10.1083/jcb.57.2.397

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Article| May 01 1973

GROWTH INHIBITION OF MURINE TUMOR CELLS, IN VITRO, BY PUROMYCIN, [⁶N]O^2'-DIBUTYRYL 3',5'-ADENOSINE MONOPHOSPHATE, OR ADENOSINE : Evidence of Commitment for Cell Division

D. B. Thomas,

D. B. Thomas

From the Department of Immunology, Middlesex Hospital Medical School, London W1, England

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Gay Medley,

Gay Medley

From the Department of Immunology, Middlesex Hospital Medical School, London W1, England

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C. A. Lingwood

From the Department of Immunology, Middlesex Hospital Medical School, London W1, England

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Author and Article Information

D. B. Thomas

From the Department of Immunology, Middlesex Hospital Medical School, London W1, England

Gay Medley

From the Department of Immunology, Middlesex Hospital Medical School, London W1, England

C. A. Lingwood

From the Department of Immunology, Middlesex Hospital Medical School, London W1, England

Received: October 06 1972

Revision Received: November 14 1972

Online ISSN: 1540-8140

Print ISSN: 0021-9525

1973

J Cell Biol (1973) 57 (2): 397–405.

https://doi.org/10.1083/jcb.57.2.397

The cytostatic effects of puromycm, [⁶N]O^2'-dibutyryl 3',5'-adenosine monophosphate, and adenosine on asynchronous and synchronous cultures of the murine mastocytoma, P815Y, have been studied. Cell growth was arrested after a minimum of one further division. A model is proposed for the inhibition of cell division in which the periods of inhibition and growth arrest are separated in time by one cell cycle.

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GROWTH INHIBITION OF MURINE TUMOR CELLS, IN VITRO, BY PUROMYCIN, [6N]O2'-DIBUTYRYL 3',5'-ADENOSINE MONOPHOSPHATE, OR ADENOSINE : Evidence of Commitment for Cell Division

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GROWTH INHIBITION OF MURINE TUMOR CELLS, IN VITRO, BY PUROMYCIN, [⁶N]O^2'-DIBUTYRYL 3',5'-ADENOSINE MONOPHOSPHATE, OR ADENOSINE : Evidence of Commitment for Cell Division