The release of Hand1 (green) from the nucleolus coincides with giant cell differentiation (top to bottom).
RILEY/MACMILLAN
Differentiation of mouse trophoblast stem cells into a specialized cell type called giant cells requires Hand1, a bHLH transcription factor. Hand1 interacts with a wider variety of other bHLH partners than do others of its class. The authors thus wondered whether it might also interact with unrelated partners that help it time giant cell differentiation. Using a yeast two-hybrid approach, they found...
The Rockefeller University Press
2007
The Rockefeller University Press
2007
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