Stimulating T cells boosts ROS production (top row), but not if Bak and Bax are absent (bottom row).
THOMPSON/ELSEVIER
The two proteins, Bax and Bak, are part of the apoptotic machinery in T lymphocytes. Weeding out excess T cells turns down the immune response after a pathogen has been defeated. Mice that lack Bax and Bak in blood cells often fall victim to infections, suggesting that the two proteins are also involved in lymphocyte activation.
The researchers found that T cells missing Bak and Bax divided slowly after stimulation. Injecting bacteria into mice lacking both proteins in their lymphocytes didn't...
The Rockefeller University Press
2007
The Rockefeller University Press
2007
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