Collective guidance wisdom

Traditionally, cell migration studies focus on the responses of a single cell to guidance signals, but migrations during development and metastasis involve traveling clumps of cells. Pernille Rørth and colleagues (EMBL, Heidelberg, Germany) now show that a collective consciousness can direct the migration of cell clusters.

The team tracked two distinct migration phases—a quick start and a later, slower phase—by the border cell cluster in developing fly egg chambers. They found that the phases required different growth factor–induced signaling pathways; only the latter was controlled by MAPK and PLCγ.

While early signals were restricted to the front of the cluster's leader, the later MAPK signal was uniform throughout leading cells. How this signal could direct movement puzzled the group until they considered that the cluster might be guided...