Coilin to the centromere's rescue

Before they advance through mitosis, cells carefully check for damage to their DNA and to the spindle that helps divvy up the chromosomes. During interphase, cells also monitor the centromeres that will be necessary for chromosomes to separate, as Morency et al. show on page 757. The researchers identify a crew of proteins that hurries to marred centromeres.

Centromeres provide anchorage for kinetochores, which latch onto the spindle fibers that pull the chromosomes apart. Cells halt mitosis if kinetochores are defective. But scientists didn't know whether cells also kept track of centromere integrity.

Morency et al. had previously observed that centromeres are subject to attack by the herpes simplex virus, which spurs cells to demolish the centromere proteins CENP-A, CENP-B, and CENP-C. The researchers have now identified a novel cell response to this destruction during interphase. Three...