Vesicles delivering new surface materials in the growing bud are missing (right) when Cdk1 activity is blocked.

KELLOGG/MACMILLAN

Aprotein that pushes forward the cell cycle coordinates division with the ensuing growth of the cell surface, according to work from Derek McCusker, Douglas Kellogg (University of California, Santa Cruz, CA), and colleagues.

It's well accepted that progress through the cell cycle depends on cell growth. In contrast, says Kellogg, “general thinking held that growth is continuous and independent of the cell cycle.”

But McCusker et al. now show that Cdk1, which triggers the G1 to S phase transition in budding yeast, also directly promotes the bud's growth. Bud growth quickly stalled upon blocking Cdk1 activity. The stall stemmed from a loss of polarized secretion. Normal cells placed secretory components such as vesicle tethering proteins and a myosin motor at the growing bud tip, but these proteins...

The Rockefeller University Press
2007
The Rockefeller University Press
2007
You do not currently have access to this content.