Cycling on without centrosomes

Centrosomes are dynamic leaders that propel the cell cycle forward. Or are they followers swept along by change? On page 173, Uetake et al. offer evidence that reconciles these disparate views. The group demonstrates that, although centrosomes are not required for cell cycle progression, their loss halts the process under stressful conditions.

Researchers long thought that centrosomes were passive participants in the cell cycle. But several recent studies found that removing or injuring centrosomes prevents cells from entering S phase, suggesting that the centrosome isn't just along for the ride.

To resolve this uncertainty, Uetake et al. excised the centrosomes from two kinds of normal cells. The cells nicely rolled through G1 into S phase, suggesting that centrosomes are not normally vital for entering S phase.

To explain why previous reports found differently, the...