Keeping valves clear

Heart valves achieve an impressive balancing act—they block large vessels but only temporarily. The blockage becomes more permanent in rheumatic valvular heart disease (VHD) when tiny, new blood vessels clog the valve. Now, Masatoyo Yoshioka, Keiichi Fukuda (Keio University, Tokyo, Japan), and colleagues find that the antiangiogenic chondromodulin-I (Chm-I) normally keeps heart valves clear of new blood vessels, and its loss is associated with VHD.

The finding was waiting to be made, says Fukuda, because “nobody was interested in studying this. Valvular heart disease is common, but most cardiologists think this is a disease for cardiac surgeons, and the surgeons only do operations.”

Chm-I was already known as an antiangiogenic factor in avascular tissues of the eye and cartilage. The Tokyo group found that it was expressed in heart valves, and its deletion led to...