One Centrin2 (green) lobe associates with the old Golgi (red, A), the other with the new Golgi (B). The bi-lobed structure then separates and duplicates (C and D).

WARREN/AAAS

Centrin that is not on centrosomes may help control Golgi duplication, say Cynthia He, Marc Pypaert, and Graham Warren (Yale University, New Haven, CT).Centrins are essential components of centrosomes, which are well-known microtubule organizers. They are less well-known as organelle replicators—apicoplasts and kinetoplasts rely on centrosomes to duplicate in protozoans. Those organisms “are just protists,” says He. “So no one really paid attention [to the findings].” But she imagined they might mean that centrosomes also control Golgi replication.

She was on the right track, as the group found that loss of trypanosomal Centrin2 inhibited Golgi duplication. It was not, however, doing this job from the centrosome, but rather from an odd bi-lobed cytoplasmic structure. One lobe...

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