Aβ generation in autophagic vacuoles

Mizushima , Noboru

doi:10.1083/jcb.200508097

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Spotlight| October 10 2005

Aβ generation in autophagic vacuoles

Noboru Mizushima

Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan

Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan

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Author and Article Information

Noboru Mizushima

Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan

Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan

Correspondence to Noboru Mizushima: [email protected]

Abbreviations used in this paper: Aβ, β-amyloid; AD, Alzheimer's disease; APP, Aβ precursor protein; AV, autophagic vacuole; PS1, presenilin-1.

Received: August 15 2005

Accepted: September 02 2005

Online ISSN: 1540-8140

Print ISSN: 0021-9525

The Rockefeller University Press

2005

J Cell Biol (2005) 171 (1): 15–17.

https://doi.org/10.1083/jcb.200508097

Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of β-amyloid (Aβ) deposits called senile or neuritic plaques. Aβ is generated by the proteolytic cleavage of Aβ precursor protein (APP) by β and γ-secretases localized in the secretory and endocytic compartments. In this issue, Yu et al. (on p. 87) report a novel mechanism for the generation of Aβ peptides, which takes place in autophagic vacuoles (AVs) that accumulate in AD brains.

The Rockefeller University Press

2005

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