Mito immunity

Mitochondria may serve as a surveillance site where innate immune responses and apoptosis are coordinated, say Rashu Seth, Zhijian Chen, and colleagues (UTSW, Dallas, Texas). They base this idea on their discovery of an antiviral protein that hangs out on mitochondria.

The protein was discovered by three groups and named MAVS, VISA, and IPS-1. Overexpression of MAVS (named for its mitochondrial antiviral signaling) induces interferon expression and thus increased antiviral defenses. It operates downstream of RIG-I, which detects viral double-stranded RNA, but upstream of the NF-κB and IRF3 families of transcription factors. RNAi of MAVS abolishes viral activation of NF-κB and IRF3 and thus knocks out the antiviral response.MAVS function requires its transmembrane domain, which resembles that of the antiapoptosis protein Bcl-2. Both proteins are found on mitochondria....