LULL1 (red) draws torsinA (green) away from the nuclear envelope.
In wild-type cells, the majority of torsinA protein localizes to the lumen of the ER, while a small proportion associates with the nuclear envelope. In cells carrying the disease-associated mutation, the proportion of torsinA at the envelope increases. Furthermore, a torsinA mutant that cannot hydrolyze ATP, and therefore becomes trapped on its target protein, selectively localizes to the nuclear periphery....
The Rockefeller University Press
2005
The Rockefeller University Press
2005
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