E. coli that are young (blue) and old (red) have distinct properties.

STEWART/TIMMERMANN

There is no escape. Even the lowly Escherichia coli, which at first glance seems to go on dividing symmetrically and forever, ages over time, according to Eric Stewart, François Taddei (Inserm, Paris, France), and colleagues.

There was hope for E. coli immortality because the bug lacked obvious asymmetries. Organisms that age tend to segregate damaged molecules preferentially into a compromised parent, and that segregation often shows up as a morphological asymmetry. Furthermore, the uncompromised offspring often turns up as a juvenile form that must undergo further development or growth before being competent for reproduction. Signs of such a progression were also lacking in the case of E. coli.

Stewart and colleagues undertook a more comprehensive examination of E. coli division dynamics, using a custom-made, computerized tracking system that followed E. coli...

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