Pericentrin pivotal in primary cilia

The centrosome protein pericentrin acts as an anchor for primary cilia formation in human cells, according to a report by Jurczyk et al. (page 637). The finding further unites the centrosome and primary cilia, both of which are based around centrioles, and both of which use pericentrin as an anchor for other proteins.

The authors show that pericentrin is located not only at centrosomes but also around the centrioles at the base of primary and motile cilia. After depletion of most pericentrin using RNAi, primary cilia failed to assemble, but centrosomes could still nucleate microtubules. The divergent outcomes may result from selective depletion of pericentrin's large isoform by RNAi, with remaining smaller isoforms perhaps acting in centrosomes.

Depletion of pericentrin also disrupted the localization of both the intraflagellar transport (IFT) proteins that help build...