Antigens make a pit stop

These rest areas, called DALIS, were previously identified by the group as clumps of ubiquitinated proteins that form transiently in newly activated DCs. Newly made proteins with translational or folding errors, called DRiPs, get ubiquitinated and are a major source of antigenic peptides. But the authors find that an arrest of DRiP processing at DALIS may put this process on hold.

Using an amino acid analogue that causes premature termination to induce and track DRiPs, the authors found that the DALIS are aggregates of DRiPs, which accumulate to high levels upon DC activation. DRiPs are probably targeted to DALIS directly by the translation apparatus, as continuing translation...